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Martin G Schwacha Selected Research

Flutamide (Eulexin)

8/2008Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis.
2/2006Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1.
1/2006Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1.
5/2003Endocrine targets in experimental shock.
1/2002Gender dimorphism in immune responses following trauma and hemorrhage.

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Martin G Schwacha Research Topics

Disease

88Wounds and Injuries (Trauma)
11/2021 - 01/2002
64Hemorrhage
10/2018 - 01/2002
37Burns
01/2018 - 03/2002
29Hemorrhagic Shock
12/2009 - 01/2002
13Sepsis (Septicemia)
11/2021 - 01/2002
13Inflammation (Inflammations)
01/2021 - 04/2007
8Hypoxia (Hypoxemia)
12/2009 - 05/2002
7Multiple Trauma (Multiple Injuries)
01/2021 - 05/2013
7Edema (Dropsy)
01/2016 - 02/2007
7Body Weight (Weight, Body)
01/2015 - 11/2005
7Shock
06/2008 - 04/2003
6Lung Injury
01/2021 - 05/2006
4Infections
01/2020 - 07/2006
4Hemothorax
01/2017 - 12/2013
3Acute Lung Injury
01/2017 - 10/2010
3Pain (Aches)
01/2015 - 11/2005
2Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
01/2020 - 10/2010
2Multiple Organ Failure (MODS)
06/2012 - 05/2004
2Hypotension (Low Blood Pressure)
10/2008 - 03/2008

Drug/Important Bio-Agent (IBA)

51salicylhydroxamic acid (SHAM)IBA
03/2017 - 01/2002
44CytokinesIBA
01/2021 - 05/2002
31Interleukin-6 (Interleukin 6)IBA
03/2017 - 01/2002
21Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2014 - 01/2002
19ChemokinesIBA
01/2016 - 09/2004
18Estrogens (Estrogen)FDA Link
04/2009 - 05/2002
14Peroxidase (Myeloperoxidase)IBA
01/2017 - 02/2006
13Lactic Acid (Lactate)FDA LinkGeneric
05/2013 - 12/2003
12Interleukin-10 (Interleukin 10)IBA
03/2017 - 03/2002
10Proteins (Proteins, Gene)FDA Link
01/2021 - 07/2005
10Estradiol (Delestrogen)FDA LinkGeneric
10/2008 - 05/2002
9Estrogen ReceptorsIBA
11/2008 - 03/2003
8Nitric Oxide (Nitrogen Monoxide)FDA Link
11/2012 - 03/2002
8p38 Mitogen-Activated Protein KinasesIBA
04/2009 - 12/2003
7Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
10/2008 - 08/2006
6PlacebosIBA
01/2017 - 01/2006
6Toll-Like Receptors (Toll-Like Receptor)IBA
11/2016 - 03/2007
5InterleukinsIBA
01/2018 - 08/2006
5Interleukin-17 (Interleukin 17)IBA
01/2018 - 07/2010
5Messenger RNA (mRNA)IBA
01/2015 - 05/2004
5Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
11/2012 - 02/2005
5WortmanninIBA
12/2009 - 06/2007
5Fulvestrant (Faslodex)FDA Link
04/2009 - 02/2006
5Chemotactic FactorsIBA
10/2008 - 08/2006
5Flutamide (Eulexin)FDA LinkGeneric
08/2008 - 01/2002
5Ringer's LactateIBA
01/2008 - 06/2004
5Gonadal Steroid Hormones (Sex Hormones)IBA
09/2005 - 01/2002
4Analgesics (Analgesic Drugs)IBA
01/2015 - 11/2005
4Opiate AlkaloidsIBA
01/2015 - 11/2005
4Mitogen-Activated Protein KinasesIBA
03/2008 - 03/2006
4Interleukin-2 (IL2)IBA
06/2004 - 04/2002
4SteroidsIBA
02/2004 - 01/2002
3T-Cell Antigen Receptors (T-Cell Receptor)IBA
02/2015 - 01/2006
3NF-kappa B (NF-kB)IBA
04/2009 - 03/2007
3NAD (NADH)IBA
11/2008 - 05/2006
33-nitrotyrosineIBA
10/2008 - 06/2008
3NitratesIBA
09/2008 - 05/2006
3Interleukin-18 (Interleukin 18)IBA
03/2008 - 08/2006
3AntibodiesIBA
03/2008 - 09/2006
3Prostaglandins EIBA
01/2007 - 03/2002
3Estrogen Receptor betaIBA
09/2006 - 02/2006
3Dehydroepiandrosterone (DHEA)IBA
08/2006 - 05/2003
3ProlactinIBA
12/2003 - 01/2002
3Interleukin-3 (Interleukin 3)IBA
03/2003 - 04/2002
2HMGB1 Protein (HMG1)IBA
01/2021 - 03/2017
2Anti-Bacterial Agents (Antibiotics)IBA
10/2018 - 12/2005
2Toll-Like Receptor AgonistsIBA
11/2016 - 09/2011
2Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)IBA
06/2015 - 08/2014
2Fibrinogen (Factor I)FDA Link
12/2014 - 05/2013
2Interleukin-22 (IL-22)IBA
06/2011 - 07/2010
2Polyvinyl AlcoholIBA
01/2010 - 09/2007
2Adenosine Triphosphate (ATP)IBA
04/2009 - 05/2007
2Chemokine CXCL2IBA
10/2008 - 06/2008
2Nitric Oxide Synthase (NO Synthase)IBA
10/2008 - 08/2008
2SB 203580IBA
10/2008 - 06/2008
2Glutathione Transferase (Glutathione S-Transferase)IBA
10/2008 - 08/2008
2NG-Nitroarginine Methyl Ester (L-NAME)IBA
10/2008 - 06/2008
2Arginine (L-Arginine)FDA Link
09/2008 - 08/2006
2Androgen Receptors (Androgen Receptor)IBA
08/2008 - 01/2002
2NitritesIBA
06/2008 - 05/2006
2Hormones (Hormone)IBA
11/2007 - 05/2003
2Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
10/2007 - 09/2007
2Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
09/2007 - 03/2007
2estradiol-bovine serum albuminIBA
09/2007 - 04/2007
2Interleukin-12 (IL 12)IBA
07/2007 - 03/2002
2interleukin-1beta-converting enzyme inhibitorIBA
05/2007 - 08/2006
2Endothelin-1 (Endothelin 1)IBA
01/2007 - 09/2004
2AndrostenediolIBA
08/2006 - 02/2005
2Testosterone (Sustanon)FDA Link
01/2006 - 07/2003
2Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA
07/2005 - 12/2003
2SolutionsIBA
09/2004 - 12/2003
2Vasoconstrictor AgentsIBA
09/2004 - 12/2003
2Prolactin Receptors (Prolactin Receptor)IBA
12/2003 - 05/2002

Therapy/Procedure

50Resuscitation
10/2018 - 01/2003
30Laparotomy
01/2017 - 01/2002
7Punctures
01/2015 - 01/2002
6Ligation
08/2006 - 01/2002
4Autologous Blood Transfusion
01/2017 - 12/2013
2Therapeutics
11/2021 - 12/2005
2Mechanical Ventilators (Ventilator)
01/2020 - 10/2010
2Thoracostomy
12/2014 - 12/2013